Blocking RAS effects
نویسندگان
چکیده
منابع مشابه
Blocking oncogenic Ras signaling for cancer therapy.
The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream cytoplasmic or nuclear events. Each mammalian cell contains at least three distinct ras proto-oncogenes encoding closely related, but distinct proteins. Activating mutations in these Ras proteins result in consti...
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We congratulate Adjei (1) on his excellent, comprehensive, and timely review on Ras signaling and the therapeutic implications of blocking this signaling. Perhaps space constraints and a major focus on pharmacologic aspects prevented any discussion of a promising alternative approach to perturbing Ras membrane localization, namely, the diversion of intracellular trafficking by an intracellular ...
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Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-defined surface pockets suitable for drug binding. Only recently, such pockets have been found in the c...
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* Director of Biological Research, G. D. Searle & Co., Chicago, Illinois, U.S.A. ; Professorial Lecturer in Pharmacology, University of Illinois College of Medicine ; Lecturer in Pharmacology , North western University Medical School. 3-(3-Oxo-7 ~-acetylthio-l7-hydroxy-4-androsten-l7ce-yl) propionic acid r lactone . The possibility that a salt regulating hormone played a causative role in the p...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2013
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4033